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prodrug
prodrug
Danh từ
Số nhiều: prodrugs
This term is used exclusively within pharmacology and medicinal chemistry to describe a strategy for improving the delivery of a therapeutic agent. The primary goal is typically to overcome barriers such as poor solubility, low absorption in the gut, or rapid degradation by enzymes before the drug reaches its target site.
Because it describes a specific chemical entity, it is used in technical, scientific, and medical registers. It is not a term used in general conversation unless discussing pharmaceutical development or specific medication mechanisms.
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pharmacokineticspharmacodynamicsmetabolismbiotransformationenzymeesterasekinaseactivationbioavailabilitysolubilitypermeabilityabsorptiondistributioneliminationclearancehalf lifetoxicityefficacypotencyligandreceptorsubstratecatalysthydrolysisoxidationreductionphosphorylationmetaboliteprecursordrug deliverypharmacologybiochemistrymoleculecompoundesteramidephosphatecarbamatelipophilicityhydrophilicityblood brain barrierliverhepatocytecytoplasmplasmabloodstreamdosageadministrationoralintravenoussubcutaneoustherapeutic indexside effectsynergyantagonismagonistantagonistbioactivationcarrierlinkertargetingpharmacophorebioisosteremetabolic pathway