bioactivation

This term is used almost exclusively within biochemistry, pharmacology, and toxicology. It describes a specific metabolic paradox where the body's attempt to detoxify a substance actually transforms it into a more reactive or harmful metabolite, often leading to cellular damage or carcinogenesis.

Because it refers to a complex biochemical process, it is treated as an uncountable noun. It is not used in casual conversation and is typically found in scientific literature or medical reports to explain the mechanism of toxicity.