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clonality
This term is used almost exclusively within specialized scientific registers, particularly in oncology, immunology, and genetics. It describes a binary state (whether a population is clonal or polyclonal) or a measurable degree of genetic uniformity. In a clinical context, the term often carries a heavy diagnostic weight, as high clonality in certain cell populations is a primary marker for malignancy or autoimmune disorders.
Because it describes an abstract quality or a biological state, the word is treated as an uncountable noun. It does not refer to individual clones, but rather to the characteristic of the population as a whole. It is typically paired with adjectives such as high, low, or absolute to describe the extent of the genetic homogeneity.
Ý nghĩa
The state or quality of being clonal, specifically referring to a population of cells or organisms derived from a single ancestor through asexual reproduction.
The degree to which a group of cells or organisms shares an identical genetic makeup due to clonal expansion.
High clonality in the B-cell population often indicates a monoclonal proliferation associated with malignancy.
Ví dụ
The biopsy results confirmed the clonality of the malignant cells.
We need to determine the clonality of the B cell population to rule out lymphoma.
Does this tumor exhibit strict clonality or is it polyclonal?
The researcher noted a high degree of clonality within the sampled tissue.
If we can prove clonality, we can trace these cells back to a single progenitor.
The clonality of the leukemia cells suggests a rapid expansion from one mutated cell.
I wonder if the clonality of this colony is affected by the growth medium.
Testing for clonality is essential for an accurate diagnosis of certain blood cancers.