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Michaelis constant
This term is a specialized biochemical parameter used to quantify the relationship between the rate of an enzymatic reaction and the concentration of the substrate. It serves as a measure of the affinity of an enzyme for its substrate; a lower value indicates that the enzyme achieves half-maximum velocity at a lower substrate concentration, signifying higher affinity.
In a laboratory or clinical setting, the term is used exclusively within the context of enzyme kinetics and the Michaelis-Menten equation. It is a technical constant and is not used in general conversation or non-scientific contexts.
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Ví dụ
The Michaelis constant provides a measure of the affinity between an enzyme and its substrate.
A low Michaelis constant indicates that the enzyme achieves half-maximal velocity at a low substrate concentration.
A low Michaelis constant indicates that the enzyme achieves half-maximal velocity at a low substrate concentration.
We need to calculate the Michaelis constant to understand how this protein behaves in the cell.
Does the Michaelis constant change when we alter the pH of the buffer solution?
The researcher noted that the Michaelis constant remained stable despite the increase in temperature.
The researcher noted that the Michaelis constant remained stable despite the increase in temperature.
I wonder if this competitive inhibitor will increase the apparent Michaelis constant of the reaction.
I wonder if this competitive inhibitor will increase the apparent Michaelis constant of the reaction.
The Michaelis constant is typically denoted as Km in biochemical literature.
The Michaelis constant is typically denoted as Km in biochemical literature.
Comparing the Michaelis constant of two different enzymes helps determine which one is more efficient at low substrate levels.
Comparing the Michaelis constant of two different enzymes helps determine which one is more efficient at low substrate levels.
The plot shows a clear relationship between substrate concentration and the Michaelis constant.
The plot shows a clear relationship between substrate concentration and the Michaelis constant.