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patch clamp
This term is a highly specialized technical expression used almost exclusively within the fields of electrophysiology and neuroscience. It refers to a precise method of isolating a small patch of cell membrane to study the behavior of single ion channels, which allows for a level of resolution impossible with whole-cell recordings.
In a laboratory setting, the term is used interchangeably as both a noun referring to the apparatus or the method, and a verb describing the act of performing the measurement. Because it is a compound technical term, it does not follow the typical idiomatic patterns of general English verbs.
Meanings
Examples
The researcher used a patch clamp to measure the current of a single ion channel.
We need to patch clamp these neurons to observe the synaptic response.
The patch clamp technique revolutionized our understanding of membrane permeability.
The patch clamp technique revolutionized our understanding of membrane permeability.
I wonder if I can get a stable gigaohm seal using this patch clamp setup.
Can you help me patch clamp the cell without rupturing the membrane?
The data was collected using a high-resolution patch clamp amplifier.
He spent the entire afternoon trying to patch clamp a single oligodendrocyte.
A successful patch clamp recording requires extreme precision and a steady hand.