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supercoil
This term is primarily used in molecular biology and polymer chemistry to describe the higher-order twisting of a double helix. It describes a state of torsional strain where the DNA axis itself twists, creating a compact, three-dimensional shape that allows long genetic sequences to fit into a microscopic cellular space.
In a technical context, the term is often paired with descriptors like positive or negative to indicate the direction of the twist relative to the right-handed double helix. While it functions as both a noun and a verb, its usage is strictly limited to scientific discourse and is virtually never found in casual or metaphorical conversation.
Meanings
Examples
The DNA molecule forms a supercoil to fit inside the tiny nucleus.
Topoisomerases are enzymes that help the cell supercoil and relax DNA.
Look at how the plasmid begins to supercoil under tension.
The protein helps the double helix supercoil into a more compact shape.
I wonder if this specific sequence will cause the strand to supercoil too tightly.
Negative supercoiling allows the DNA to be more easily opened for transcription.
Negative supercoiling allows the DNA to be more easily opened for transcription.
The long polymer chain will supercoil if you continue to twist it.
Does the DNA supercoil differently in prokaryotes compared to eukaryotes?
Does the DNA supercoil differently in prokaryotes compared to eukaryotes?