Nota: A tradução desta entrada está atualmente em revisão de qualidade, portanto parte do conteúdo é exibida temporariamente apenas em inglês.
Este verbete ainda não foi traduzido para o seu idioma, portanto o original é exibido abaixo.
paratope
This term is a highly specialized technical descriptor used almost exclusively within immunology and biochemistry. It describes the precise physical geometry and chemical environment of an antibody's binding site, creating a lock-and-key relationship with the antigen. It carries a neutral, clinical connotation and is never used in casual conversation.
Because it refers to a specific structural component of a protein, it functions as a standard countable noun. It is typically paired with adjectives describing specificity, affinity, or conformation to detail how an antibody interacts with its target.
Meanings
Examples
The antibody paratope binds specifically to the antigen epitope.
I wonder if a single mutation in the paratope could abolish the binding affinity.
The structural complementarity between the paratope and the epitope is essential for recognition.
The structural complementarity between the paratope and the epitope is essential for recognition.
Look at how the paratope fits perfectly into the groove of the protein.
The variable region of the immunoglobulin contains the paratope.
We need to analyze the amino acid sequence of the paratope to understand its specificity.
The paratope recognizes a specific three dimensional shape on the surface of the pathogen.
Does this monoclonal antibody have a high affinity paratope for the target receptor?