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isoform
This term is used exclusively within biochemistry and molecular biology to describe functional variations of a single protein. It carries a neutral, technical connotation and is used to specify precise molecular differences that might affect how a protein behaves in different tissues or developmental stages.
Because it refers to a specific molecular entity, it is treated as a standard countable noun. Researchers typically discuss "multiple isoforms" when referring to the various versions of a protein produced through alternative splicing or different gene loci.
Meanings
Examples
The researchers identified a specific isoform of the protein that is only expressed in cardiac tissue.
The researchers identified a specific isoform of the protein that is only expressed in cardiac tissue.
Which isoform are we targeting for this particular assay?
Which isoform are we targeting for this particular assay?
Alternative splicing can lead to the production of multiple isoforms from a single gene.
I wonder if this isoform has a higher affinity for the ligand than the others.
The drug is designed to selectively inhibit one isoform without affecting the others.
Different isoforms often exhibit distinct kinetic properties despite their similar functions.
We need to determine if the observed effect is due to a specific isoform.
The expression levels of each isoform vary significantly across different developmental stages.
The expression levels of each isoform vary significantly across different developmental stages.