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Este verbete ainda não foi traduzido para o seu idioma, portanto o original é exibido abaixo.
holoenzyme
This term describes the functional state of an enzyme, emphasizing the synergy between the protein component and its non-protein helper. It carries a connotation of completeness and operational readiness, distinguishing a biologically active unit from its inactive precursor.
In biochemical literature, the word is used strictly within technical contexts to describe the assembly of complex catalysts. It is a precise scientific designation rather than a general descriptive term, typically appearing in discussions regarding metabolic pathways and enzymatic regulation.
Meanings
Examples
The reaction cannot proceed until the apoenzyme and cofactor assemble into a functional holoenzyme.
I wonder if this specific holoenzyme requires a zinc ion to maintain its structural integrity.
Without the coenzyme, the protein remains inactive and cannot form the holoenzyme.
The researcher observed that the holoenzyme exhibited a much higher affinity for the substrate.
Wait, so the holoenzyme is just the active version of the enzyme, right?
Binding of the prosthetic group converts the inactive apoenzyme into a catalytic holoenzyme.
The stability of the holoenzyme is crucial for the metabolic pathway to function correctly.
We need to isolate the holoenzyme from the cellular lysate to study its kinetics.