Nota: A tradução desta entrada está atualmente em revisão de qualidade, portanto parte do conteúdo é exibida temporariamente apenas em inglês.
Este verbete ainda não foi traduzido para o seu idioma, portanto o original é exibido abaixo.
isogenic
This term is used almost exclusively within the specialized registers of genetics, molecular biology, and agricultural science. It describes a state of total genetic uniformity, typically achieved through controlled breeding or cloning, to eliminate genetic noise in experimental data.
In a laboratory setting, isogenic lines serve as the gold standard for control groups. By ensuring that two groups are isogenic, researchers can confidently attribute any observed phenotypic differences to external variables, such as drug treatment or environmental stress, rather than inherent biological variation.
Meanings
Examples
The researchers used an isogenic line to ensure that any observed differences were due to the experimental treatment.
The researchers used an isogenic line to ensure that any observed differences were due to the experimental treatment.
We need to establish an isogenic control group for this study.
Are these two cell lines truly isogenic or is there a slight variation in their genomes?
The study compared isogenic pairs of mice to isolate the effect of a single gene mutation.
By using isogenic plants, the botanist could rule out genetic diversity as a variable.
I wonder if the isogenic nature of the sample will affect the results of the sequencing.
The lab specializes in creating isogenic strains for cancer research.
The two organisms are essentially isogenic, differing only by a single nucleotide polymorphism.
The two organisms are essentially isogenic, differing only by a single nucleotide polymorphism.