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frameshift

A genetic mutation caused by the insertion or deletion of a number of nucleotides in a DNA sequence that is not divisible by three, resulting in a shift of the reading frame and the alteration of all subsequent amino acids in the protein. / To cause a shift in the reading frame of a genetic sequence through the addition or removal of nucleotides.
NounTransitive Verb
pl: frameshiftspast: frameshiftedpp: frameshifteding: frameshifting

This term is a highly specialized technical expression used almost exclusively in genetics and molecular biology. It describes a catastrophic error in the translation of genetic code, where the entire reading frame of a DNA or RNA sequence is displaced, typically leading to a non-functional protein or a premature stop codon.

In a clinical or research context, the word carries a strong connotation of disruption and dysfunction. It is rarely used metaphorically in general English, as its meaning is tied strictly to the triplet nature of codons in biological sequences.

Meanings

Noun

A genetic mutation caused by the insertion or deletion of a number of nucleotides in a DNA sequence that is not divisible by three, resulting in a shift of the reading frame and the alteration of all subsequent amino acids in the protein.

The patient's condition was caused by a frameshift mutation in the CFTR gene.

Transitive Verb
[~ something]

To cause a shift in the reading frame of a genetic sequence through the addition or removal of nucleotides.

The insertion of a single base pair can frameshift the entire downstream sequence of the mRNA.

Examples

A single nucleotide deletion can cause a catastrophic frameshift in the protein sequence.

none

A single nucleotide deletion can cause a catastrophic frameshift in the protein sequence.

Wait, if one base is added here, does that frameshift the entire downstream sequence?

School Life

Waitif one base is added heredoes that frameshift the entire downstream sequence?

The patient has a rare genetic disorder caused by a frameshift mutation in the CFTR gene.

Health

The patient has a rare genetic disorder caused by a frameshift mutation in the CFTR gene.

I wonder if this specific insertion will frameshift the reading frame enough to create a premature stop codon.

none

I wonder if this specific insertion will frameshift the reading frame enough to create a premature stop codon.

The mutation is a frameshift that completely alters the resulting amino acid chain.

none

The mutation is a frameshift that completely alters the resulting amino acid chain.

We need to determine if the deletion will frameshift the gene or if it is a multiple of three.

School Life

We need to determine if the deletion will frameshift the gene or if it is a multiple of three.

This frameshift leads to a nonfunctional protein that cannot catalyze the reaction.

none

This frameshift leads to a nonfunctional protein that cannot catalyze the reaction.

Could a frameshift be responsible for the sudden change in the protein's phenotype?

none

Could a frameshift be responsible for the sudden change in the protein's phenotype?

The lab results confirm a frameshift mutation in the third exon.

Health

The lab results confirm a frameshift mutation in the third exon.

Related Words

mutationcodondeletioninsertiontranslationtranscriptionribosomemRNAtRNAamino acidproteinpolypeptidegenomegenenucleotidebase pairDNARNAgenetic codeallelechromosomegeneticsmolecular biologybiochemistryprotein synthesistruncationelongationinitiationterminationenzymepolymeraseexonintronsplicingmutation ratephenotypegenotypeheredityevolutionselectionadaptationpathologydiseasesyndromeprotein foldingmisfoldinganticodonpeptide bondnucleosidegenetic driftcytoplasmnucleusorganellebiotechnologysequencingbioinformatics
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