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tight junction
This term is a technical biological descriptor used primarily in histology and cell biology. It describes a specific type of intercellular seal that regulates the permeability of epithelial and endothelial layers, ensuring that substances must pass through the cells rather than between them.
In a clinical or research context, the term is often discussed in relation to the blood-brain barrier or the intestinal lining. It is a precise anatomical term and does not have a metaphorical or casual equivalent in standard English usage.
Meanings
Examples
The tight junction prevents ions from leaking between the cells.
Do these proteins actually form the tight junction seal?
A damaged tight junction can lead to increased intestinal permeability.
A damaged tight junction can lead to increased intestinal permeability.
I need to remember that the tight junction is located at the apical end of the cell.
The tight junction acts as a selective barrier for the organism.
Wait, so the tight junction essentially zips the membranes together?
Certain toxins can disrupt the integrity of the tight junction.
The blood-testicular barrier relies on a specialized tight junction.