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monomania
This term describes a specific type of obsession where the mind is consumed by one single subject to the exclusion of all other rational concerns. It carries a clinical or psychological connotation, suggesting a state of imbalance or mental fixation that borders on the pathological, rather than a healthy passion or hobby.
In modern usage, it is often employed metaphorically to describe an intense, narrow focus in professional or creative pursuits. While "obsession" is a broad term, "monomania" specifically emphasizes the singularity of the focus, implying that the individual has become blind to everything else in their environment.