Nota: A tradução desta entrada está atualmente em revisão de qualidade, portanto parte do conteúdo é exibida temporariamente apenas em inglês.
Este verbete ainda não foi traduzido para o seu idioma, portanto o original é exibido abaixo.
proteasome
This term is a technical biological designation used primarily in biochemistry and cell biology. It describes a specific molecular machine responsible for protein degradation, often referred to as the cell's garbage disposal system. Because it is a highly specialized scientific term, it is almost exclusively found in academic papers, medical textbooks, and laboratory reports rather than in general conversation.
In a clinical or research context, the word is frequently associated with the ubiquitin-proteasome system, where proteins are tagged for destruction. Understanding this term is crucial for discussing oncology and immunology, as many chemotherapy drugs specifically target these complexes to induce apoptosis in cancer cells.
Meanings
Examples
The 26S proteasome is the primary machinery for protein degradation in the cell.
I wonder if the proteasome is functioning correctly in these mutated cells.
Certain cancer drugs work by inhibiting the proteasome to trigger cell death.
Check the assay to see if the proteasome activity has increased.
The ubiquitin tag signals the proteasome to destroy the target protein.
We need to determine how the proteasome recognizes this specific substrate.
Proteasome dysfunction is often linked to neurodegenerative diseases.
Proteasome dysfunction is often linked to neurodegenerative diseases.
The structure of the proteasome resembles a hollow cylinder.