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zymogen
This term is used exclusively within biochemistry and medical contexts to describe the dormant state of certain enzymes. It conveys a sense of biological safety, as zymogens prevent enzymes from digesting the very tissues that produce them until they reach their intended destination.
In a laboratory or clinical setting, the term is often contrasted with the active enzyme. For example, pepsinogen is the zymogen form of pepsin. The transition from zymogen to active enzyme is typically an irreversible process involving the removal of a masking sequence of amino acids.
Meanings
Examples
The body produces a zymogen to prevent the enzyme from digesting the organ that creates it.
Is this protein a zymogen or is it already in its active form?
Pepsinogen is the zymogen form of pepsin.
Pepsinogen is the zymogen form of pepsin.
I wonder if this specific zymogen requires a cofactor for activation.
The activation of a zymogen usually involves the irreversible cleavage of a peptide bond.
The activation of a zymogen usually involves the irreversible cleavage of a peptide bond.
We need to isolate the zymogen before it converts into an active protease.
A zymogen remains dormant until it encounters a specific trigger in the environment.
The blood clotting cascade relies on the sequential activation of several zymogens.
The blood clotting cascade relies on the sequential activation of several zymogens.