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occludin
Occludin is a highly specialized technical term used almost exclusively in molecular biology, histology, and pathology. It describes a specific protein that acts as a seal between cells, ensuring that fluids and solutes do not leak between the gaps of the epithelial or endothelial layers.
Because it refers to a specific molecular entity, the term is used in a descriptive, scientific register. It is typically paired with verbs like "express," "downregulate," or "localize" when discussing the protein's presence or behavior within a cellular membrane.
Meanings
A transmembrane protein that is a key component of tight junction strands in epithelial and endothelial cells, playing a critical role in regulating the permeability of the paracellular pathway.
The expression of occludin is often downregulated during the process of epithelial-mesenchymal transition.