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endonuclease

An enzyme that cleaves the phosphodiester bond within a polynucleotide chain, cutting the DNA or RNA molecule at a site other than the ends.
Noun
pl: endonucleases

This term is a specialized technical noun used almost exclusively within molecular biology, biochemistry, and genetics. It describes a specific class of enzymes characterized by their ability to cut internal bonds of a nucleic acid strand, distinguishing them from exonucleases, which remove nucleotides only from the ends of the chain.

In a laboratory setting, the term is frequently paired with the adjective "restriction" to describe enzymes that recognize and cut specific DNA sequences. Because it is a scientific term, it maintains a neutral, objective register and is rarely used outside of academic or medical contexts.

Meanings

Examples

The restriction endonuclease cuts the DNA at a specific recognition sequence.

School Life

We need to use a site-specific endonuclease to fragment the plasmid.

Office

I wonder if this endonuclease will produce blunt or sticky ends.

I wonder if this endonuclease will produce blunt or sticky ends.

The cell activates an endonuclease to degrade the viral genome.

The cell activates an endonuclease to degrade the viral genome.

Health

Did you add the endonuclease to the reaction buffer yet?

Did you add the endonuclease to the reaction buffer yet?

Office

Apoptosis involves the activation of a specialized endonuclease that cleaves chromatin.

Apoptosis involves the activation of a specialized endonuclease that cleaves chromatin.

Health

The researcher observed that the endonuclease cleaved the RNA strand internally.

This specific endonuclease is essential for the process of DNA repair.

This specific endonuclease is essential for the process of DNA repair.

School Life

The enzyme acts as an endonuclease by breaking phosphodiester bonds within the chain.

The enzyme acts as an endonuclease by breaking phosphodiester bonds within the chain.

Related Words

Última actualización: May 2026Reportar un error