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allostery
This term is a specialized technical noun used almost exclusively within biochemistry and molecular biology. It describes a specific mechanism of enzyme regulation where the protein changes shape upon binding a ligand, thereby altering its affinity for other substrates. Because it describes a biological process or phenomenon, it is treated as an uncountable mass noun.
In a professional scientific register, it is often contrasted with competitive inhibition. While competitive inhibition involves molecules fighting for the same active site, allostery involves a "remote control" effect where the regulatory site is physically distinct from the active site.
Meanings
Examples
The professor explained how allostery allows for the fine tuning of enzyme activity.
I wonder if this specific protein exhibits allostery when bound to the ligand.
Allostery is a fundamental mechanism for maintaining homeostasis within the cell.
Allostery is a fundamental mechanism for maintaining homeostasis within the cell.
Look at this graph to see how allostery changes the binding affinity.
The drug was designed to target the site of allostery rather than the active site.
We need to determine if the inhibition is competitive or based on allostery.
The complex nature of allostery makes it a challenging subject for undergraduates.
Could allostery be the key to unlocking this metabolic pathway?
Many hemoglobin functions are governed by the principles of allostery.
Many hemoglobin functions are governed by the principles of allostery.