লক্ষ্য করুন: এই এন্ট্রির অনুবাদ বর্তমানে মান পর্যালোচনার অধীনে রয়েছে, তাই কিছু বিষয়বস্তু সাময়িকভাবে শুধুমাত্র ইংরেজিতে প্রদর্শিত হচ্ছে।
এই এন্ট্রিটি এখনও আপনার ভাষায় অনুবাদ করা হয়নি, তাই নিচে মূল লেখাটি দেখানো হচ্ছে।
bioactivation
This term is used almost exclusively within biochemistry, pharmacology, and toxicology. It describes a specific metabolic paradox where the body's attempt to detoxify a substance actually transforms it into a more reactive or harmful metabolite, often leading to cellular damage or carcinogenesis.
Because it refers to a complex biochemical process, it is treated as an uncountable noun. It is not used in casual conversation and is typically found in scientific literature or medical reports to explain the mechanism of toxicity.
Meanings
Examples
The prodrug requires bioactivation by liver enzymes to become therapeutically active.
Is the toxicity caused by the parent compound or by its bioactivation in the kidney?
Bioactivation of certain polycyclic aromatic hydrocarbons can lead to DNA damage.
I wonder if this specific enzyme is responsible for the bioactivation of the toxin.
The researcher focused on the bioactivation pathway to understand the drug's mechanism.
Without proper bioactivation, the medication remains inert and ineffective in the body.
Without proper bioactivation, the medication remains inert and ineffective in the body.
We must determine whether bioactivation occurs primarily in the liver or the lungs.
The process of bioactivation often transforms a harmless molecule into a reactive electrophile.