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methotrexate
Methotrexate is a highly technical medical term used primarily in clinical settings. It belongs to a class of drugs known as antimetabolites. In a medical context, it is discussed in two distinct capacities: as a high-dose chemotherapy agent for treating certain cancers, and as a low-dose disease-modifying antirheumatic drug (DMARD) for autoimmune conditions like rheumatoid arthritis.
Because it is a potent medication with a narrow therapeutic window, the register surrounding its use is typically formal and precise. Conversations involving methotrexate often focus on "titration" (adjusting the dose) and "monitoring" (regular blood tests to check liver and kidney function).
A critical pragmatic point in English usage is the emphasis on the dosing frequency. Unlike many medications taken daily, methotrexate for autoimmune diseases is typically administered once weekly. Therefore, phrases emphasizing the "weekly schedule" are common and vital for patient safety to avoid accidental overdose.
Meanings
A medication used to treat cancer, rheumatoid arthritis, and psoriasis by inhibiting folate metabolism.
Take methotrexate.
Examples
The doctor prescribed methotrexate to manage my rheumatoid arthritis.
I need to take folic acid to reduce the side effects of methotrexate.
Is methotrexate administered as a pill or an injection?
The patient showed a positive response to the methotrexate treatment.
I wonder if the methotrexate is starting to work yet.
Methotrexate is often used as a first line of defense against psoriasis.
Make sure you do not miss your weekly dose of methotrexate.
The oncologist explained how methotrexate inhibits cell growth in the tumor.