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autocrine
This term is used exclusively within biological and medical contexts to describe a specific mechanism of cellular communication. It describes a self-stimulating loop where a cell acts as both the sender and the receiver of a chemical signal, creating a localized feedback system that can amplify a specific biological response.
In clinical research, the term often carries a connotation of uncontrolled growth or self-sufficiency, particularly when discussing oncogenesis, where autocrine signaling allows cancer cells to stimulate their own proliferation independently of external growth factors.
Meanings
Examples
The cell regulates its own growth through an autocrine signaling loop.
Wait, does this specific cytokine have an autocrine effect on the T cell?
Many cancer cells develop autocrine loops to stimulate their own proliferation.
I wonder if the receptor is sensitive enough to trigger an autocrine response.
Autocrine stimulation allows a cell to maintain its own identity during development.
Autocrine stimulation allows a cell to maintain its own identity during development.
The research paper describes an autocrine mechanism that triggers apoptosis.
This protein acts in an autocrine fashion to reinforce the cellular signal.
We need to determine if the ligand is acting in a paracrine or autocrine manner.