Nota: A tradução desta entrada está atualmente em revisão de qualidade, portanto parte do conteúdo é exibida temporariamente apenas em inglês.
Este verbete ainda não foi traduzido para o seu idioma, portanto o original é exibido abaixo.
pyrogen
This term is used almost exclusively within medical, pharmacological, and laboratory contexts. It describes a specific biological trigger for fever, often associated with endotoxins from Gram-negative bacteria. In a clinical setting, the term carries a high-stakes connotation, as the presence of pyrogens in injectable drugs can lead to severe, life-threatening systemic inflammatory responses.
Because it refers to a specific class of chemical or biological agents, it is typically used in technical discussions regarding sterilization, vaccine purity, and blood-product safety. It is rarely encountered in general conversation outside of healthcare or biochemistry.
Meanings
Examples
The lab technician must ensure the vials are free of any pyrogen before use.
Is this batch of saline tested for pyrogen contamination?
Is this batch of saline tested for pyrogen contamination?
A pyrogen can trigger a rapid increase in body temperature.
I wonder if the fever was caused by an endogenous pyrogen released by the immune system.
The pharmaceutical company implemented strict filters to remove every trace of pyrogen.
Endotoxins are a common type of pyrogen found in Gram-negative bacteria.
The patient reacted poorly because the injection contained a pyrogen.
We need to verify that the sterilization process eliminated the pyrogen.
The presence of a pyrogen in the bloodstream signals the hypothalamus to raise the temperature set point.
The presence of a pyrogen in the bloodstream signals the hypothalamus to raise the temperature set point.